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Name Nardil
Generic name Phenelzine
Manufacturer Pfizer Inc., Parke-Davis Division
First used in FDA-approved in 1959
Family MAOIs
Indications Social Anxiety Disorder, Depression, Panic Disorder


How does it work? By inhibiting monoamine oxidase (MAO) enzymes, phenelzine slows down the metabolism of neurotransmitters such as epinephrine, norepinephrine, serotonin, and dopamine, and thus keeps them longer in the brain. Phenelzine also elevates levels of the neurotransmitter GABA.
Clinical trails suggest phenelzine is at least as effective as other commonly used drugs for conditions such as Social Anxiety, and real-world testimonials suggest it is even better. Even though, phenelzine is usually indicated only for patients who have failed to respond to safer drugs, such as SSRIs. High blood pressure prevention is critical during treatment with phenelzine. Therefore, several foods, beverages and medications must be avoided. One of the substances that should be avoided is tyramine.

Side effects: Dizziness, drowsiness, sleeping problems, stomach and intestines problems, weight gain, high/low blood pressure, dry mouth, sexual side effects.

Withdrawal: Especially when stopped abruptly, withdrawal reactions may occur. They may include flu-like symptoms, sleep disturbances, nausea, agitation, strange behavior, convulsions and hallucinations.

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MEMBERS' NOTES (first is most recent) ADD NOTE     SORT BY: NAME / DATE
Live long and try to be happy...

Many of your posts have given me a lift.

Thanks Luigi! Happy Birthday!

Been going a little nuts here trying to get some help for this deep depression with anxir=ety. On list for trial of Ketamine, am trying a small amount of Suboxone (suppose to help deep depression), checking into Vagus Nerve Stimulation, got taken off Cymbalta -- that stuff can make you NUTS! Ahhhh! Pardon the sickness Only Nardil Worked For Me / Pfizer You Have Horribly Affected Hundreds of Wonderful People. Die. And Rot in Hell. Bastards.

Stay Well everyone. It's the only thing that makes life worth living... All my best.
   (Thu Jul 3 21:33 2008)

HI
Thanks YOU for you support:FORGETFUL MARY-JOE and to all my friends.
God will help us....I am sure not by the big corporate......what ever the names
Again Thank you and the good GOD bless you
Luigi   (Thu Jul 3 21:01 2008)

Dan--sorry you are having trouble....I got a bit better with Nardil after trying Parnate unsuccessfully. I think someone mentioned taking a break and going back to Nardil and having some improvement. I understand Parnate also was made generic and cheapened as well. I feel for ya....If you do try Parnate beware the high blood pressure...mine spiked really high on it.....   (Thu Jul 3 19:56 2008)

Hi Luigi ...Glad you are still here!! In spite of the crummy corporate thieves and bought off FDA!!! We will survive !!!   (Thu Jul 3 19:53 2008)

Happy Birthday ! From southern California
Hope you had a good one,hang in there.   (Thu Jul 3 19:22 2008)

Hi Dan
I did try Cymbalta ....It is a waste of time same as the new Nardil
If you can, try to stay away from any new meds.......Are made only to get your money
Take care my friend
Luigi   (Thu Jul 3 17:28 2008)

HI All
Yesterday was my birthday.......Today I am one day older> I did reach 75 in spite of Pfizer (the nonsense new formula)
Take care my friends
Luig (Canada)   (Thu Jul 3 14:01 2008)

Dan by joe
Hi Dan hang in there ,I would try Parnate
if you can get the Brand name not the generic. It worked better than Cymbalta for me.Yes, I started Nardil again hoping to feel the way I did Before Pfizer changed it to a brand name generic. The first week I got
really sick so I stopped for a week - I restarted a week ago now I just feel weird, I
don't know if I got a bad Batch or what.The problem,besides being a really crappy med., is that Pfizer has no Quality control .Every time you get a prescription you don't know if it's good or bad.And a good batch will never help you like the original Park -davis Nardil did - a bad batch of this new Pfizer
Nardil will just about kill you.I never had
a bad batch of Parnate the quality control
is pretty good- in that respect alone go with the Parnate first.Good luck, Maybe somebody else has something to add ?   (Tue Jul 1 1:59 2008)

Joe, are you on Nardil again? How are you feeling? Does it work at all?

Has anyone been on Cymbalta?

Anyone know if Parnate was changed?

Everyone. I could use some real help.
I am full of anxiety and need help.

   (Mon Jun 30 20:28 2008)

Dan by joe
Hey Dan
I think they did mess with the Parnate a while back they said the coating was changed.
How it affected the way it works ? One would have to be taking it before the change to note the effect.The person who may know is NYMarine .Most of us here know how the change
in Nardil did us in .Thanks to Vicki Camp
and Dr.Bob for this web site- we never whould have known what the hell was going on.
But now we do ,so if you read the letters
on the npac site - which are really great
letters - to the FDA and others- you will see
that we are up a creek.However,don't give up hope.I'm sure there will be some type of breakthrough in this field.Then we can tell Pfizer to stick it.   (Mon Jun 30 13:39 2008)

Good to see you still out there. How are you doing on your current Nardil attempt?

Saw your advice to Tired333 - never ceases to amaze me how many people could benefit from good old Nardil. I agree that Parnate would be a better choice for an MAOI right now, but it should be name brand and should also probably be combined again with his Klonopin upped or Valium added. Parnate tends to be energizing. But it is really worth a try if you have never gone with an MAOI before -- this advice would state NARDIL instead of Parnate if they hadn't F***ed up that wonderful drug. It still, however, may work better for Tired333 than what he is currently taking.

I have been fighting my own fight with a change to the SSRI & NRI camp. God these things are awful; full of side effects and not much benefit. Glad I've got my Ativan.

Dan
   (Thu Jun 26 20:05 2008)

Thanks for the information on Nardil. It seems every forum I go to people are saying Nardil is now crap. That doesn't give me lot of hope to try it. Well I missed my appointment today anyways so at least I have more time to think about this. Has anyone tried Parnate that has also been on Effexor, Klonapin, and not a low dose of Klonapin. I used to take 6mg all at once in the morning and pretty much counted down 7 hours before I got too nervous again. If anyone has had success with Parnate please let me know.    (Thu Jun 26 11:16 2008)

I hate to tell you this but you're about 4 yrs. to late - the old Nardil worked Great
for social phobic problems . But Pfizer got control of it and changed the formula now it's pure crapp.I think you may have better luck with Parnate( Brand name) the product is more consistant - with Pfizer the variation from each batch is : Bad to just dump it down the toilet. Good luck   (Thu Jun 26 0:22 2008)

Recently I have done some huge medication changes and am now looking at Nardil. I was on 6mg of Klonapin and 150mg Effexor XR for the last 3 years. Basically I felt like a non emotional idiot but I could at least hold a job. After 30 days in a rehab I been changed to 2mg klonapin and 1200mg of Trileptal. Put on about 20 pounds and am now housebound again. I stopped taking the trileptal today considering it didn't do crap for my anxiety..oh and neither does Remeron, but it's a great sleeping pill. I have my great emergency appointment tomorrow and thought I'd try an MAOI this time. Just like many people I've seen on here, I've tried everything. I heard that Nardil was good for social phobia but now that I read this thread I'm skeptical. Is Nardil no more effective then Paxil, Effexor or Klonapin? It doesn't seem like it works too well from reading all of this. Any advise would be greatly appreciated.    (Wed Jun 25 19:19 2008)

Interesting article but it is over 2 years old. An update would be nice. Also are they making anymore SSRI's or are they all done with those?   (Tue Jun 24 0:41 2008)

GlaxoSmithKline's NS2359 and Merck's dov216303 are "Triple Uptake Inhibitors" that are presently in production. Glaxo's TRI could launch in 2009 and Merck's TRI could launch in 2011, but the point is that these are the first two new antidepressant medications to come along in a very long time. Each is a reuptake blocker of Serotonin, Norepinephrine, and Dopamine. If only they also worked on GABA and you repsonded well to reuptake blockers, you would have some real hope. You could use Neurontin to attempt to imitate GABA, but this does not necessarily work all of the time.

Here's a link to the article. I hope that some of us respond to this, because I most definitely respond to some serotonin reuptake blockers.

http://biopsychiatry.com/antidepressants/triple.html

These will replace many medications meaning most of the SSRIs and perhaps some of the older tricyclics. Keep it in mind, please and pass it along as well.   (Mon Jun 23 21:26 2008)

The only form of Therapy that works, provided you have no neurochemical unbalances in your nervous system is Congnitive Behavior Therapy. Although a few other forms are practiced this is your best shot.

Good luck!   (Thu Jun 19 22:20 2008)

Well, I'm off Cymbalta for 3 days now. I have been spending most of the last 2 days crying and sleeping. Also, my left ear is clogged up and my hearing is slightly impired...could that be a withdrawal symptom??? I think I have had it with meds. Going on and coming off so many different medications is driving me crazy...oh wait, I think I already was crazy! Then, this must be making me super crazy. Anyway, I think just being me might be better than all of this medicine nonsence. At least I'll know it's me and not some medicine making me feel wacky!

Maybe it's time to go back to talk therapy and get rid of these Psychiatrists who just want to hand out meds like candy. Bad doctors, bad medicines, bad, bad, bad!

Please forgive my silliness...it's either that or tears...or sleep. Too bad I can't sleep 24/7...

Take care all...hugs,

Vicky   (Thu Jun 19 16:48 2008)

If you need the new Nardil, maybe I can help you.Send me an email I will give you a telephone number, and you can call ERFA your selfe
Have a nice day   (Mon Jun 16 14:04 2008)

I just got some Nardil from Artie and they were much redder than the orange Pfizer. Does anyone know if there are different ingrediants in them besides coloring? They seem to work better too.

Thanks Artie read my email and best of luck with the battle we fight.   (Thu Jun 12 22:38 2008)

every 3 months sounds like an eternity to me. I can barely get a months supply. It's always 2 weeks lately. But I'm not paying this jerk if he doesn't do what I say this time.

I wake up with panic attacks every morning so maybe that might be better is taking a least 1 right before bed. Usually I just run down stairs and pop a nardil and 1mg klonopoin and feel creepy till they kick in.    (Thu Jun 12 10:48 2008)

I take my 3 Nardil in the evening.....I used to take them all in the morning. You might try asking a Primary Dr to give you a prescription. I got tired of my DR ripping me off by making me see him every 3 months....Finally asked my GP to write me an RX after telling her I hsave been on it forever--(25 years).She wrote me an RX for a year!!! YAY!!!   (Wed Jun 11 21:00 2008)

Well I was doing pretty good on 20mg Paxil but then I got sad on cloudy days and we bumped it up to 30mg and I put on 10 pounds in 12 days so I said thats all folks. Plus Paxil changes your personality till you become an uncaring robot bastard. At least it did to me.

As for the new Nardil having never tried the old one I can say it has been working fairly well even at a low dose of 30mg then 45mg even under some of the worst stress of my life. I still think that one Lithium I took messed me up because I wake up having a panic attack this morning and I get sad at certain times of the day and know it is time to pop a Nardil. I wonder if I should just take all 3 right off in the morning.

Also called over 30 doctors numbers today and left at least 15 different messages,(some out of service) and of the ones that take both new patients and Medicare only 1 called back to say he takes no insurance at all. Tomorrow I'm going to dig in and call some more but it is very depressing and nerve racking knowing you only have 7 days left of Nardil and your current doctor is a a-hole. I could always take a Paxil if it gets too bad and risk serotone syndrome but we'll see. Hopefully Jeff comes through with the extra pills he has but I am preparing for the worst.
   (Mon Jun 9 22:30 2008)

Yeah I'm in no rush to go any higher than 45mg but I think I need to adjust when I take them or something. 3 times a day isn't quite right and taking one before bed makes me have dry mouth in the morning. I think I'll try I in the morning 1 at mid day and then one around 8pm.

I checked the bottle of mine and it says Pfizer. I think the last couple days of feeling bad has nothing to do with the pills and more to do with family and that one doctor stressing me out.

I noticed jumping to 45 mg has made me feel more bloated in the gut but I haven't changed weight at all but I do worry big time about weight gain because I blew up to 250 pounds on Paxil after a couple years and ended up gtting so obsessive compulsive about dieting after I quit Paxil I lost 100 pounds and looked like a heroin addict. I have stayed at about 165-168 since starting Nardil though and sleep is pretty good.

Anyways nice to hear from you Artie.   (Sun Jun 8 22:17 2008)

I just sent you an e-mail.

About your other question, I would say that there's very little difference between the country versions of Nardil. They'll either continue to work for someone, or they won't. The only big difference, in my opinion, is whether a certain manufacturing plant is cranking out bad batches or not. To my knowledge, the U.K. and Australia don't, but Pfizer and Erfa do, due to lack of quality control as NY Marine just indicated.

And if you think you need to up your dosage in the future to 75-90 mg, which is where I decided to say enough was enough, then I don't know whether that's a good or bad sign. I couldn't afford to go past 90, so I had no choice but to quit. I hope in your case you fair better.   (Sun Jun 8 21:03 2008)

Hey Artie you still around? You get my emails?

to all: I was thinking how I started taking Nardil for Social anxiety at first but now I have depression bad and panic attacks as well. It's working ok for SA but I think I have to go up on my dose. Probably 15mg every month until I am at 75-90mg. This doctor doesn't see that 30mg is causing breakthrough anxiety and depression which is pretty sad when he says he has been a doctor for something like 30 years. Also this jerk made me suffer 14 days on nothing when I got off of Paxil to start Nardil just so he could pull this low dose crap.

   (Sun Jun 8 11:41 2008)

The sad thing is this is an old doctor who should know better. He's probably like late 50's maybe 60 ish.

I tool one 450mg lithium and it was a nightmare. I hated it. Anyways I've been taking 45mg a day for about a week now and I feel better. The only "problem" is that he is only prescribing 30mg so I will run out soon and have to either look for a new doc, call him and tell him I upped the dose without his permission or hopefully get a bottle from Artie.

Also to anyone: Do all the Nardil manufacturers (Pfizer, Link Concord...) pills look the same orange? ANd how would you tell what type you have. I get mine at CVS. What brand would that be?   (Sat Jun 7 23:05 2008)

sounds like the idiot DR of yours deserves a damn good Bronx beat down. you are so right. fight to get the extra 15 mgs and no lithium EVER   (Sat Jun 7 14:26 2008)

Luigi, i agree but to get the correct inactive ingredients is a crap shot. even the crap pfiser makes in France/Belgium has absolutely no quality control. i have heard methocel is good...fact is no person had found an anwer in over 5 1/2 years   (Sat Jun 7 14:22 2008)

Phenelzine Sulphate minus Excipients, is =
Drive a CAR without wheels or without a steering wheel.
Please dont attempt to drive this tablet inside your stomach...The tablet can loose the
proper funtion or direction.
If I am wrong!.....Ask Pfizer, then they should know better
Take care my friends   (Sat Jun 7 10:39 2008)

Hi this guy is so spitful he only is prescribing me two week prescriptions at a time. Just so he can string me along and go back to him. Also because he's greedy. I have to pay $27 every visit and he gets something like another $100+ from medicare.

Personally I feel like crap after I see him because all he wants to do is turn me into a zombie even though he made me suffer two weeks with no Paxil while I made the switch.   (Fri Jun 6 22:31 2008)

This guy says he has been doing this longer than I have been alive (26 years) and he says he has a guy on 105 mg but he is just being stubborn and says no one he treats has had any problems with the new nardil.

Also since my memory is cooked I am also the user reallycrazy because I forgot I made this account.   (Fri Jun 6 22:26 2008)

Hey Art do you still have any of those Nardil pills left? I need to find out if my theory is correct or not.    (Fri Jun 6 15:10 2008)

Whenever I take a 15mg nardil and 1mg klonopin I get a huge burst of energy after about 30 minutes and it lasts for like 4-5 hours and then I totally flatline and can barely walk if I'm in a store until I take more Nardil.

Is this normal or is it mania like my doctor thinks but which I refuse to agree with because I'm not on enough Nardil only 30mg a day?

I never had any sort of bipolar tendancies all my life and I don't believe they would just start up now over 30mg of Nardil which I feel great on.   (Fri Jun 6 15:05 2008)

Joe by Dan
Thanks for your help, Joe. I appreciate the support. Dan   (Fri Jun 6 1:40 2008)

PS where's MT Tabor?   (Thu Jun 5 16:44 2008)

Art It's a shame that you never got to be on
the original Nardil - It was a truely amazing
med.- What they try to pass off as Nardil now
is at least 98% something else.Ask any of the old timmers.3.5 of the original pills
would take you from the bottom of the pit and
put you on top of the mountain.I'm not talking about being "High" ,it just cleared
all the gray out of your mind so you could
be who you were ment to be.I'm sure others out there could tell it better than me.
I wish you the best
Joe   (Thu Jun 5 16:43 2008)

I did that once, by putting 3 of the tablets under my tongue, and it gave me a massive headache. I figured that by doing that it would immediately get into the blood stream and into the brain, but after getting that headache, it occurred to me that Nardil needs to be a slow- and consistent-release process, something which I already knew about, but didn't think about at that time.

But I agree that being put on too many medications isn't a good thing. It could have very high hedonistic backlashes when trying to get off them. I know somebody from another forum who's on about a dozen medications, including a few dietary supplements. He gets them all for free since he lives in Canada of all places, but I think some doctors just like to hand out meds like candy because they, the healthcare system, and government, get more money from such publicly-financed healthcare systems, and all at the expense of the patients that don't know what the future holds for them if they ever have to get off all those meds. But the guy in question still isn't able to become independent in life even being on all those meds, so something tells me he's going to be in for a rough future when withdrawal time comes around, and I know there's many more like him too.   (Thu Jun 5 3:06 2008)

If anybody would like 3 unopened bottles of Nardil, just send me an e-mail. If I had known tolerance would have developed in me in the way that it did, then I wouldn't have bought that many at a time. But as long it helps somebody else out for whom the medication still works for, then I know it won't completely go to waste, even if I will be out over $270... but, that's the luck of the draw I guess.

P.S. and please, no reselling them.   (Thu Jun 5 2:36 2008)

Dan by Joe
Dan If you're still on the nardil- Have you tried wiping off the orange color and letting
the pills desolve under your tongue?Your doc
wants to put you on 4 different meds? Thats
insane .He/she needs to know whats going on
have your doc check out this site. Good luck
Joe   (Wed Jun 4 2:03 2008)

Hi Dan:
As I said, watch the mega-hunger with Zyprexa. My doc said to just cut down on calories and try exercise. HA! I wish I could have!

Also, to anyone with ANXIETY, I found something that really works. Magnesium.
It quells the anxiety and helps you sleep.
3 weeks ago I started with 600 mg. The results were amazing. What a sense of peace and calmness.
Then I got indigestion and stomachaches.
I have since stopped it, and will try again with 300 mg. This is truly worth a try.

I read much on this mineral, and saw it on Oprah too.
The hardest thing is getting the correct dosage without stomach problems. I heard to try about 200 - 800 mg per day.
Give it 3 weeks to kick in.

Good luck to all.
Helen
   (Mon Jun 2 13:50 2008)

I did received a letter from HEALTH CANADA, saying: Bla bla bla-:In this case, a notice of compliance(NOC) was issued to Pfizer Canada for marketing of re-formulated Nardil in January 2004. The NOC was BASED on
data from CLINICAL TRIAL in HEALTHY volunteers, wich provided evidence that the rate and extent of absorpion of Phenelzine
Sulphate by the body was the same with the
re-formulated Nardil as it was with the original formulation.........
--------------------------------------------
I HAVE A "CD" WHERE PROVE THAT SUCH CLINI-
CAL TRIAL WAS NEVER DONE!-
therefore Government and BIG pharma......They belong to the same CLUB
Finally I realize we are in a hopeleness position.
Only God can help us
Take care my friends (rarely I will post)
Luigi
   (Sun Jun 1 21:29 2008)

Joe, did you feel any better OFF the Nardil?
Good luck on your new attempt.

Helen, thanks -- Dr. wants to put me on Zyprexa and Abilify; and Ritalin and Lithium in smaller amounts. Why the heck does he think I'm on Valium. ANXIETY!
Anxiety mixed with depression with chronic pain.

Atypical depression. Nardil worked. Doc wants to try maybe Cymbalta or Wellbutrin after getting me off Nardil. WHAT IS IT ABOUT US THAT MADE THE MAOIs THE BEST THING TO FIX ALL THESE PROBLEMS WITH JUST ONE COMPOUND.

I never imagined that I would be so sick again -- always was grateful to have that nice little brown and white Parke Davis bottle on my shelf. The contents were magic. A little, hard coated orange pill that took its time to dissolve and then went to work in just the right areas of my brain...

Thanks Mary. Thanks Dave. Thanks NY Marine. Thanks Artie. Thanks Luigi. Thanks everyone...

Dan
   (Sun Jun 1 5:25 2008)

In the end Pfizer cares a whole lot more about it's stock price and how much its CEO made in cash, than she ever did about us.

It's a real pity that we could not effect any change in that company -- other than to further alienate her.   (Sat May 31 10:21 2008)

Thank you for the info.......But I did reach the finishing line. You me and many more did indeed waste lot of time (about 4 years) in this nonsense Phenelzine Sulfate. I have to admit we did help somehow each other.
I did try......But Pfizer stay the same: Dont care about you and me.   (Fri May 30 18:17 2008)

Yes, I know where Stan L. is. He's back working as a PA in LA.
   (Fri May 30 12:51 2008)

Thank you both for your input. I really appreciate it. Having a rough time now. Trying to figure out what to do. Dan   (Fri May 30 1:50 2008)

Does any of you know where is and what happen to STAN L. ??????
Stan come back here, we need you
Luigi   (Thu May 29 20:44 2008)

I had artificial starvation syndrome too when Nardil was working for me, except that it was candy instead of food (assuming one doesn't consider candy actual food), and it wasn't just having the munchies for candy, it was an insatiable craving for it. I don't know if Nardil gave me low blood sugar or the aforementioned syndrome, but I tell you, I was eating candy just about all day, from the time I woke up, until the time I went to sleep. It was absolutely nuts. Nothing bad came out of that, except gained a little weight from it, but I don't have any such craving anymore, which I didn't really consider good or bad; just neutral.

That wasn't the reason why I stopped Nardil, which was due to it just not working anymore at a given dosage, and theoretically any given dosage. Would the old Nardil have done the same thing for me or continue to work long-term? There's no way for me to know.

As an aside, instead of buying Gabitril, which is a GRI, and not exactly cheap or easy to come by, I'll just have to get by with Klonopin alone, and titrate accordingly. Regarding what Nardil is "supposed" to do, benzos take care of the GABA component, while L-Dopa, an inexpensive supplement which I plan on trying, takes care of the dopamine factor since it's a precursor to DE and also crosses the BBB. As for the other neutrotransmitters -- serotonin, epinephrine, and norepinephrine -- I haven't looked into single supplements which are direct precursors to them, but as I'm writing this right now, it just occurred to me that it couldn't hurt to look.   (Thu May 29 7:53 2008)

Sure. My e-mail address should appear in my profile by clicking on my name, but if it isn't showing up for whatever reason, then it's artbell2012@yahoo.com   (Thu May 29 7:15 2008)

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